Cyfuse Regenova overview

The Cyfuse Regenova is a 3D bioprinter made by Cyfuse Biomedical K.K., a Japanese manufacturer based in Tokyo.

Bioprinting is the precise depositing of biomaterials such as cells, proteins, bacteria and bio-gels in 2D or 3D. This technology can be used as a tool in high-throughput applications, or to mimic biological systems that are more closer and accurate to the actual living systems for research, testing and diagnosis.

The Cyfuse Regenova turns living cell aggregates into artificial human tissue, and both companies say the tissue cultures will soon be used to test new products – and might eventually be used to construct human organs from an individual’s own stem cells.

The Cyfuse Regenova uses cultured cellular aggregates called ‘spheroids’ which are place on fine needle arrays. The spheroid cells then form a connected, macro-level structure over time without the use of collagen or hydrogel, the building blocks of current methods. Composed of tens of thousands of cells per spheroid, the cultures are placed in a “bioreactor” for days or weeks where aggregation takes place to create the 3D tissues.